Nesvategrast [1621332-91-9]
HY-117133
CAS Number1621332-91-9
Product group Chemicals
Molecular Weight475.49
Overview
- SupplierMedChem Express
- Product NameNesvategrast [1621332-91-9]
- Delivery Days Customer10
- CAS Number1621332-91-9
- CertificationResearch Use Only
- Molecular FormulaC23H27F2N5O4
- Molecular Weight475.49
- Scientific DescriptionNesvategrast (SF0166) is a potent and selective alphavbeta3 antagonist with IC50 values of 0.6 nM, 8 nM, and 13 nM for alphavbeta3, alphavbeta6, and alphavbeta8, respectively. Nesvategrast inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 values of 7.6 pM to 76 nM. Nesvategrast decreases neovascularization in the oxygen-induced retinopathy mouse model[1].
- SMILESOC(C[C@@H](C1=CN=C(OC(F)F)C=C1)N2C(N(CCCC(N3)=CC=C4C3=NCCC4)CC2)=O)=O
- UNSPSC12352200