NF-kappaB-IN-16

MedChem Express

NF-kappaB-IN-16

5

Research Use Only

C26H35Cl3N2O10Pt

837.01

NF-kappaB-IN-16 (compound 9) is a complex (Pt(IV) complex) of NF-kappaB inhibitor and Cisplatin (HY-17394), which has high efficacy and low toxicity in anti-tumor activity. active. NF-kappaB-IN-16 can cause DNA damage, induce mitochondrial dysfunction, produce reactive oxygen species, and induce apoptosis through the mitochondrial pathway and endoplasmic reticulum stress. NF-kappaB-IN-16 potently inhibits the NF-kappaB/MAPK signaling pathway and disrupts PI3K/AKT signaling. NF-kappaB-IN-16 also exhibits excellent in vivo antitumor efficiency and low toxicity in A549 or A549/CDDP xenograft models[1].

COC1=C(C(OC)=CC(C(/C=C/C2=CC=C(C(OCCOC(CCCC(O[Pt]([NH3])(Cl)(Cl)([NH3])Cl)=O)=O)=C2)OC)=O)=C1)OC

12352200