NF-kappaB-IN-19

MedChem Express

NF-kappaB-IN-19

5

Research Use Only

C24H26Cl3F2N3O4Pt

759.92

NF-kappaB-IN-19 (Compound 8) is an NF-kappaB inhibitor. NF-kappaB-IN-19 effectively induces DNA damage, promotes the generation of ROS, and induces autophagy and apoptosis through the NF-kappaB signaling pathway in tumor cells. In addition, NF-kappaB-IN-19 can inhibit the levels of VEGF and HIF-1alpha, and exert antiproliferative activity in tumor cells through the PI3K/AKT and STAT-3 pathways. NF-kappaB-IN-19 can effectively overcome cisplatin resistance and has anti-tumor activity[1].

O=C(CCCC(O[Pt]([NH3])(Cl)(Cl)([NH3])Cl)=O)N1C/C(C(/C(C1)=C/C2=C(C=CC=C2)F)=O)=C\C3=CC=CC=C3F

12352200