NF-kappaB-IN-5 [2425675-52-9]

MedChem Express

NF-kappaB-IN-5 [2425675-52-9]

10

2425675-52-9

Research Use Only

C23H27N3O4

409.48

NF-kappaB-IN-5 (compound 4d) is an orally active and potent NF-kappaB inhibitor by interacting directly with NF-kappaB. NF-kappaB-IN-5 shows antitumor activity against human cancer cell lines (HCT116, U87-MG, HepG2, BGC823, PC9), with IC50 values of 5.35, 2.81, 2.83, 2.02 and 3.90 microM, respectively. NF-kappaB-IN-5 induces apoptosis in U87-MG tumor cell and cell cycle arrest in G0/G1 phase[1].

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12131703