NF-kappaB/MAPK-IN-1 [2413940-56-2]

MedChem Express

NF-kappaB/MAPK-IN-1 [2413940-56-2]

10

2413940-56-2

Research Use Only

98.71

C27H27NO7

477.51

NF-kappaB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-kappaB and MAPK pathway. NF-kappaB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC50 of 6.96 microM. NF-kappaB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERkappa and P38 signaling activation. NF-kappaB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-kappaB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research[1].

O=C(NC1=CC=C(OC2=CC(OC)=CC=C2C(C)=O)C=C1)/C=C/C3=CC(OC)=C(OC)C(OC)=C3

-20°C,2°C to 8°C

12131703