NF157 [104869-26-3]

MedChem Express

NF157 [104869-26-3]

10

104869-26-3

Research Use Only

92.90

C49H28F2N6Na6O23S6

1437.10

NF157 is a highly selective nanomolar P2Y11 antagonist with a pKi of 7.35. The IC50s are 463 nM, 1811 microM, 170 microM for P2Y11 (Ki=44.3 nM), P2Y1 (Ki=187 microM), P2Y2 (Ki=28.9 microM), respectively[1]. NF157, significantly reduces expression of metalloproteinase (MMP)-3, MMP-13, can be used in the treatment of osteoarthritis (OA)[2].

O=C(NC1=CC(C(NC2=CC(C(NC3=CC=C(S(=O)(O[Na])=O)C4=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C34)=O)=CC=C2F)=O)=CC=C1)NC5=CC(C(NC6=CC(C(NC7=CC=C(S(=O)(O[Na])=O)C8=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C78)=O)=CC=C6F)=O)=CC=C5

2°C to 8°C

12352200