NF449 (octasodium)

MedChem Express

NF449 (octasodium) [627034-85-9]

10

627034-85-9

Research Use Only

99.0

C41H24N6Na8O29S8

1505.09

NF449 octasodium is a highly potent P2X 1 receptor antagonist, with IC 50 s of 0.28, 0.69, and 120 nM for rP2X 1 , rP2X 1+5 , P2X 2+3 , respectively. NF449 octasodium is a G salpha -selective G Protein antagonist. NF449 octasodium suppresses the rate of GTP[gammaS] binding to G salpha-s , inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of beta-adrenergic receptors to G s [1] [2] .

O=C(NC1=CC(C(NC2=CC=C(S(=O)(O[Na])=O)C=C2S(=O)(O[Na])=O)=O)=CC(C(NC3=CC=C(S(=O)(O[Na])=O)C=C3S(=O)(O[Na])=O)=O)=C1)NC4=CC(C(NC5=CC=C(S(=O)(O[Na])=O)C=C5S(=O)(O[Na])=O)=O)=CC(C(NC6=CC=C(S(=O)(O[Na])=O)C=C6S(=O)(O[Na])=O)=O)=C4

-20°C

12352200