NF449 (octasodium) [627034-85-9]

MedChem Express

NF449 (octasodium) [627034-85-9]

10

627034-85-9

Research Use Only

99.0

C41H24N6Na8O29S8

1505.09

NF449 octasodium is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. NF449 octasodium is a Gsalpha-selective G Protein antagonist. NF449 octasodium suppresses the rate of GTP[gammaS] binding to Gsalpha-s, inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of beta-adrenergic receptors to Gs[1][2].

O=C(NC1=CC(C(NC2=CC=C(S(=O)(O[Na])=O)C=C2S(=O)(O[Na])=O)=O)=CC(C(NC3=CC=C(S(=O)(O[Na])=O)C=C3S(=O)(O[Na])=O)=O)=C1)NC4=CC(C(NC5=CC=C(S(=O)(O[Na])=O)C=C5S(=O)(O[Na])=O)=O)=CC(C(NC6=CC=C(S(=O)(O[Na])=O)C=C6S(=O)(O[Na])=O)=O)=C4

-20°C

12352200