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NFAT Inhibitor-1 (VIVIT peptide)

NFAT Inhibitor-1 (VIVIT peptide)

M1261
AbMole BioScience
CAS Number249537-73-3
DownloadDatasheet
DownloadMSDS
Product group Chemicals
Estimated Purity 99.02%
Molecular Weight1685.94
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    NFAT Inhibitor-1 (VIVIT peptide)
  • Delivery Days Customer
    9
  • CAS Number
    249537-73-3
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Estimated Purity
    99.02%
  • Molecular Formula
    C75H120N20O22S
  • Molecular Weight
    1685.94
  • Scientific Description
    NFAT Inhibitor-1 (VIVIT peptide) is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT), it is superior at inhibiting calcineurin-mediated dephosphorylation of NFAT1, NFAT2, and NFAT4 in cell extracts. NFAT Inhibitor treatment significantly inhibits nuclear translocation of NFATc1 for 24 hours. Long-term treatment with VIVIT significantly inhibits the cytoplasmic levels of cathepsin K, TRAP, and MMP-9. Sequence: Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu
  • Storage Instruction
    Store at ≤ -20°C, sealed
  • UNSPSC
    12352200

References

  • Gao J, Liu J, Lu J, et al. Skap1 expression in cancer cells enhances colon tumor growth and impairs cytotoxic immunity by promoting neutrophil extracellular trap formation via the nfatc1/cxcl8 axis. Adv Sci (Weinh). 2024;11(41):e2403430.
    Read more
  • Filla MS, Faralli JA, Dunn CR, Khan H, Peters DM. Nfatc1 regulation of dexamethasone-induced tgfb2 expression is cell cycle dependent in trabecular meshwork cells. Cells. 2023;12(3):504.
    Read more