Western Blot analysis of 1) Hela, 2) 293T, 3) HepG2 cells using NFkappaB-p65 Monoclonal Antibody at dilution of 1:2000.
Western Blot analysis of 1) Hela, 2) 293T, 3) HepG2 cells using NFkappaB-p65 Monoclonal Antibody at dilution of 1:2000.
NFkB p65 Monoclonal Antibody
E-AB-22016
Product group Antibodies
Overview
- SupplierElabscience
- Product NameNFkB p65 Monoclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionProteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel,are members of a family of transcription factors that include the two subunits of the transcription factor NFkappaB (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp kappaB sequence in the immunoglobulin kappa light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NFkappaB is activated and NFkappaB is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.
- UNSPSC12352203