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ProductsBack/NGD9002 (free base) [666256-06-0]

NGD9002 (free base) [666256-06-0]

HY-118935
MedChem Express
CAS Number666256-06-0
Product group Chemicals
Molecular Weight357.49
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Overview

  • Supplier
    MedChem Express
  • Product Name
    NGD9002 (free base) [666256-06-0]
  • Delivery Days Customer
    9
  • CAS Number
    666256-06-0
  • Certification
    Research Use Only
  • Molecular Formula
    C20H31N5O
  • Molecular Weight
    357.49
  • Scientific Description
    NGD9002 free base is a new generation of selective corticotropin-releasing factor-1 (CRF-1) receptor antagonist with inhibitory activity on CRF-induced colonic function stimulation. NGD9002 free base can reduce CRF-induced fecal output response and show an inhibitory IC50 value of 4.3 mg/kg. NGD9002 free base can effectively block CRF-induced colonic secretory motility stimulation at the highest dose and reduce acute water avoidance-induced defecation. NGD9002 free base can also prevent the occurrence of pain hypersensitivity reactions to repeated colonic distension[1].
  • SMILES
    CC1=C(N=C(C(NC(CC)CC)=N1)OC)C2=CC=C(N=C2NC)C(C)C
  • UNSPSC
    12352200

MSDS

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