NH2-methylpropanamide-Exatecan (TFA) [1817857-35-4]

MedChem Express

NH2-methylpropanamide-Exatecan (TFA) [1817857-35-4]

14

1817857-35-4

Research Use Only

99.80

C30H30F4N4O7

634.58

NH2-methylpropanamide-Exatecan TFA is a methylpropanamide-modified Exatecan (HY-13631), which is the common ADC Cytotoxin used in the synthesis of ADC. Exatecan is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 microM (0.975 microg/mL), and can be used in cancer research[1].

OC(C(F)(F)F)=O.NC[C@H](C)C(N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62)=O

-20°C

41115800