NHEJ inhibitor-1

MedChem Express

NHEJ inhibitor-1

10

Research Use Only

C30H35N7O8PtS

848.79

NHEJ inhibitor-1 (Compound C2) is a trifunctional Pt(II) complex, alleviates the non-homologous end connection (NHEJ)/homologous recombination (HR)-related double strand breaks (DSBs) repairs to evade Cisplatin-resistance in non-small cell lung cancer (NSCLC). NHEJ inhibitor-1 inhibits the damage repair proteins Ku70 and Rad51 to make tumors re-sensitive to Cisplatin. NHEJ inhibitor-1 also induces ROS generation and MMP deduction[1].

[H][C@]12CS[C@H]([C@]1(NC(N2)=O)[H])CCCCC(NCCN3C(C4=CC=CC5=C4C(C3=O)=CC=C5/N=C6CC7(C(O[Pt]([NH3])(OC7=O)[NH3])=O)C/6)=O)=O

12131703