NHLRC1 Antibody

Cusabio

NHLRC1 Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

NHLRC1

NHL repeat containing E3 ubiquitin protein ligase 1

EPM2A, EPM2B, MALIN, MELF2, bA204B7.2, E3 ubiquitin-protein ligase NHLRC1, NHL repeat containing 1, NHL repeat-containing protein 1, RING-type E3 ubiquitin transferase NHLRC1

Rabbit

IgG

E3 ubiquitin-protein ligase NHLRC1

E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.

Human, Rat

-20°C or -80°C

41116161