NI-42 [1884640-99-6]

MedChem Express

NI-42 [1884640-99-6]

5

1884640-99-6

Research Use Only

98%

C18H15N3O3S

353.4

NI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM) with excellent selectivity over nonclass IV BRD proteins.

O=S(C1=CC=C(C#N)C=C1)(NC2=CC=C(N(C)C(C(C)=C3)=O)C3=C2)=O

-20°C,-80°C

12352200