NI-42

MedChem Express

NI-42 [1884640-99-6]

10

1884640-99-6

99.53

C18H15N3O3S

353.40

NI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs ( IC 50 s of BRPF1/2/3=7.9/48/260 nM; K d s of BRPF1/2/3=40/210/940 nM) with excellent selectivity over nonclass IV BRD proteins [1] .

O=S(C1=CC=C(C#N)C=C1)(NC2=CC=C(N(C)C(C(C)=C3)=O)C3=C2)=O

-20°C

12352200