NIC-0102 [2806031-94-5]

MedChem Express

NIC-0102 [2806031-94-5]

10

2806031-94-5

Research Use Only

98.72

C21H25BF2N2O4

418.24

NIC-0102 is an orally active proteasome inhibitor (pIC50=7.55) that specifically inhibits NLRP3 inflammatory vesicle activation. NIC-0102 shows potent anti-inflammatory effects in a model of dextran sulfate sodium (DSS)-induced ulcerative colitis. NIC-0102 also inhibits production of pro-IL-1beta[1].

CC(C[C@@H](B(O)O)NC([C@@H](NC(C1=C(C=CC=C1F)F)=O)CC2=CC=CC=C2)=O)C

-20°C,2°C to 8°C

12131703