Nic-15

Biorbyt

Nic-15

10

Research Use Only

98.00%

C25H26F2O3

412.47

Nic-15 (compound 4n) serves as an anti-constrictive agent targeting the low vascular characteristics of pancreatic tumors. These characteristics enable cancer cells to adapt to the nutrient-deficient tumor microenvironment and develop resistance to treatment. Nic-15 modulates the PI3K/Akt/mTOR pathway and alleviates ER stress induced by Gemcitabine. It significantly inhibits migration and colony formation in MIA PaCa-2 and PANC-1 pancreatic cancer cells. When used in combination with Gemcitabine, Nic-15 effectively addresses resistance issues in pancreatic tumors. In xenograft models in vivo, Nic-15 notably enhances the efficacy of Gemcitabine.

C(=O)([C@H]1[C@@H](CC(CCC=C(C)C)=CC1)C2=C(F)C(F)=CC=C2)C3=C(O)C=CC=C3O

-20°C

12352200