Nifurpirinol [13411-16-0]

MedChem Express

Nifurpirinol [13411-16-0]

10

13411-16-0

Research Use Only

98.70

C12H10N2O4

246.22

Nifurpirinol (P-7138) is a selective prosubstrate of bacterial nitroreductase (NTR). NTR catalyzes the reduction of nifurpirinol to generate cytotoxic metabolites that induce apoptosis in target cells. Nifurpirinol selectively ablates NTR-expressing cells such as pancreatic beta cells, osteoblasts, dopaminergic neurons, and podocytes in transgenic zebrafish models. Nifurpirinol can be used in regeneration studies and disease modeling such as focal segmental glomerulosclerosis (FSGS)[1][2].

OCC1=NC(/C=C/C2=CC=C([N+]([O-])=O)O2)=CC=C1

-20°C,2°C to 8°C

12131703