Nigericin (sodium salt)

MedChem Express

Nigericin (sodium salt) [28643-80-3]

10

28643-80-3

Research Use Only

99.37

C40H67NaO11

746.94

Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/beta-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC[1][2][3][4][5][6][7].

C[C@H]1[C@](O[C@@H]2C[C@](CC[C@@H]3C)([H])O[C@@]3([H])[C@@H](C)C(O[Na])=O)([C@@H]([C@H](OC)C2)C)O[C@](C)([C@@]4([H])O[C@@](C)([C@@]5([H])O[C@@]([C@]([C@@H](C[C@@H]6C)C)([H])O[C@]6(O)CO)([H])C[C@H]5C)CC4)C1

2°C to 8°C

12352200