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Nigericin (sodium salt)

HY-100381
MedChem Express
CAS Number28643-80-3
DownloadMSDS
Product group Chemicals
Estimated Purity99.37
Molecular Weight746.94
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Nigericin (sodium salt) [28643-80-3]
  • Delivery Days Customer
    10
  • CAS Number
    28643-80-3
  • Estimated Purity
    99.37
  • Molecular Formula
    C40H67NaO11
  • Molecular Weight
    746.94
  • Scientific Description
    Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K + /H + ionophore , promoting K + /H + exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt / beta-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1 /GSDMD in TNBC [1] [2] [3] [4] [5] [6] [7] .
  • SMILES
    C[C@H]1[C@](O[C@@H]2C[C@](CC[C@@H]3C)([H])O[C@@]3([H])[C@@H](C)C(O[Na])=O)([C@@H]([C@H](OC)C2)C)O[C@](C)([C@@]4([H])O[C@@](C)([C@@]5([H])O[C@@]([C@]([C@@H](C[C@@H]6C)C)([H])O[C@]6(O)CO)([H])C[C@H]5C)CC4)C1
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200