NIPBL antibody, Internal

GeneTex

NIPBL antibody, Internal

7

This antibody is expected to recognize both reported isoforms (NP_597677.2; NP_056199.2).

ICC/IF: 10microg/ml. IHC-P: 2microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

0.50 mg/ml

Unconjugated

NIPBL

NIPBL cohesin loading factor

CDLS; CDLS1; delangin; IDN3; IDN3-B; Nipped-B homolog; nipped-B-like protein; Scc2; SCC2 homolog; sister chromatid cohesion 2 homolog

Goat

IgG

Nipped-B-like protein

This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Human

-20°C or -80°C,2°C to 8°C

12352203