Bio-Connect

Nirogacestat

HY-15185
MedChem Express
CAS Number1290543-63-3
Product group Chemicals
Estimated Purity99.78
Molecular Weight489.64
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Nirogacestat [1290543-63-3]
  • Delivery Days Customer
    5
  • CAS Number
    1290543-63-3
  • Certification
    Research Use Only
  • Estimated Purity
    99.78
  • Molecular Formula
    C27H41F2N5O
  • Molecular Weight
    489.64
  • Scientific Description
    Nirogacestat (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective gamma-secretase inhibitor with an IC 50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers [1] .
  • SMILES
    FC1=C2C(CC[C@H](N[C@@H](CCC)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O)C2)=CC(F)=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200