NKG2D blocking peptide
GTX89520-PEP
Product group Proteins / Signaling Molecules
Overview
- SupplierGeneTex
- Product NameNKG2D blocking peptide
- Delivery Days Customer9
- CertificationResearch Use Only
- Scientific DescriptionNatural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed ce
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352202