NKH477

MedChem Express

NKH477 [138605-00-2]

9

138605-00-2

Research Use Only

99.86

C27H44ClNO8

546.09

NKH477 (Colforsin dapropate hydrochloride) directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 is a forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts [1] .

O[C@@]12[C@@]3([C@@](C(C)(CC[C@@H]3O)C)([H])[C@H](OC(CCN(C)C)=O)[C@H](OC(C)=O)[C@]1(O[C@](C=C)(C)CC2=O)C)C.Cl

-20°C

12352200