NL-103 [1788896-33-2]

TargetMol Chemicals

NL-103 [1788896-33-2]

72

Research Use Only

NL-103

C26H27Cl2N5O4

544.43

NL-103 is a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations. NL-103 comprises structural elements of Hh pathway inhibitor vismodegib, and histone deacetylase (HDAC) inhibitor vorinostat. NL-103 simultaneously and significantly inhibited both HDACs and Hh pathway. Importantly, NL-103 effectively overcame vismodegib resistance induced by Smoothened point mutations. Moreover, NL-103 significantly downregulated the expression of Gli2 which plays an important role in Hh pathway. NL-103 may be a promising compound for clinical development as a more effective Hh pathway inhibitor.

3 years

N(C(=O)C1=CC(Cl)=CC=C1)C2=CC(NC(=O)C=3C=CC(NCCCCCCC(NO)=O)=NC3)=CC=C2Cl

-20°C

12352200