NL13

MedChem Express

NL13

9

Research Use Only

C22H19Cl2NO2

400.30

NL13 is a Polo-like kinase 4 (PLK4) inhibitor with an IC50 value of 2.32 microM. NL13 can inhibit the viability of PC3 and DU145 prostate cancer cells, with IC50 values of 3.51 microM and 2.53 microM, respectively. NL13 can lead to the inactivation of the AKT signaling pathway by downregulating CCNB1/CDK1, inducing G2/M cell cycle arrest, and triggering apoptosis through the cleavage of caspase-9/caspase-3. In prostate cancer mice, NL13 can inhibit tumor growth[1].

ClC1=C(/C=C2CN(C(CC)=O)C/C(C\2=O)=C\C3=CC=CC=C3Cl)C=CC=C1

12352200