NL13
ORB2663622
Estimated Purity98.00%
Product group Chemicals
Molecular Weight400.3
Overview
- SupplierBiorbyt
- Product NameNL13
- Delivery Days Customer10
- CertificationResearch Use Only
- Estimated Purity98.00%
- Molecular FormulaC22H19Cl2NO2
- Molecular Weight400.3
- Scientific DescriptionNL13, a Polo-like kinase 4 (PLK4) inhibitor, exhibits an IC 50 value of 2.32 microM. It demonstrates the ability to suppress the viability of PC3 and DU145 prostate cancer cells with respective IC 50 values of 3.51 microM and 2.53 microM. NL13 also inhibits tumor growth in prostate cancer mice. Additionally, it deactivates the AKT signaling pathway by reducing CCNB1/CDK1 levels, leading to G2/M cell cycle arrest and initiating apoptosis through caspase-9/caspase-3 cleavage.
- Storage Instruction-20°C
- UNSPSC12352200