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NLG919 [1402836-58-1]

NLG919 [1402836-58-1]

Research Use Only
27337
BPS Bioscience
CAS Number1402836-58-1
Product group Chemicals
Estimated Purity≥98%
Molecular Weight282.4 Da
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Overview

  • Supplier
    BPS Bioscience
  • Product Name
    NLG919
  • Delivery Days Customer
    7
  • CAS Number
    1402836-58-1
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Molecular Formula
    C18H22N2O
  • Molecular Weight
    282.4 Da
  • Scientific Description
    NLG919 is an orally available potent inhibitor of the indoleamine-2,3- dioxygenase (IDO) pathway, a crucial pathway involved in allergic inflammation that mediates immunosuppressive effects through metabolization of tryptophan to kynurenine. NLG919 affects differentiation and proliferation of T cells by inducing downstream signaling via GCN2, mTOR and AHR, with values of Ki = 7 nM and EC50 = 75 nM. NLG919 is being investigated for the treatment of immunosuppression associated with cancer.
  • UNSPSC
    51202000