NLG919 [1402836-58-1]
27337
CAS Number1402836-58-1
Product group Chemicals
Estimated Purity≥98%
Molecular Weight282.4 Da
Overview
- SupplierBPS Bioscience
- Product NameNLG919
- Delivery Days Customer7
- CAS Number1402836-58-1
- CertificationResearch Use Only
- Estimated Purity≥98%
- Molecular FormulaC18H22N2O
- Molecular Weight282.4 Da
- Scientific DescriptionNLG919 is an orally available potent inhibitor of the indoleamine-2,3- dioxygenase (IDO) pathway, a crucial pathway involved in allergic inflammation that mediates immunosuppressive effects through metabolization of tryptophan to kynurenine. NLG919 affects differentiation and proliferation of T cells by inducing downstream signaling via GCN2, mTOR and AHR, with values of Ki = 7 nM and EC50 = 75 nM. NLG919 is being investigated for the treatment of immunosuppression associated with cancer.
- UNSPSC51202000
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