Bio-Connect

NLRP3-IN-8 [2768650-56-0]

HY-146594
MedChem Express
CAS Number2768650-56-0
Product group Chemicals
Molecular Weight420.41
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Overview

  • Supplier
    MedChem Express
  • Product Name
    NLRP3-IN-8 [2768650-56-0]
  • Delivery Days Customer
    10
  • CAS Number
    2768650-56-0
  • Certification
    Research Use Only
  • Molecular Formula
    C23H20N2O6
  • Molecular Weight
    420.41
  • Scientific Description
    NLRP3-IN-8 (compound 27) is an orally active, directly binding NLRP3 inflammasome inhibitor with an IC50 value of 1.23 microM against IL-1 beta. NLRP3-IN-8 has good metabolic stability to liver microsomes (t1/2 = 138.63 min), and has almost no toxicity (against L02: IC50 > 100 microM)[1].
  • SMILES
    COC1=CC(OC)=C(C(/C=C/C2=CC=C(C=C2)NC(C3=CC=CO3)=O)=C1)/C=C/[N+]([O-])=O
  • UNSPSC
    12131703