NME2 / nm23-H2 / NDPK-B (Suppressor of Metastasis)(CPTC-NME2-2), CF740 conjugate, 0.1mg/mL

Biotium

NME2 / nm23-H2 / NDPK-B (Suppressor of Metastasis)(CPTC-NME2-2), CF740 conjugate, 0.1mg/mL

16

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

CPTC-NME2-2

0.1 mg/ml

Other Conjugate

NME2

NME/NM23 nucleoside diphosphate kinase 2

NDKB, NDPK-B, NDPKB, NM23-H2, NM23B, PUF, nucleoside diphosphate kinase B, HEL-S-155an, NDP kinase B, c-myc purine-binding transcription factor PUF, c-myc transcription factor, epididymis secretory sperm binding protein Li 155an, histidine protein kinase NDKB, non-metastatic cells 2, protein (NM23) expressed in, non-metastatic cells 2, protein (NM23B) expressed in, nucleotide diphosphate kinase B

IgG2a

Nucleoside diphosphate kinase B

The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines, one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells. Based on sequence analysis, nm23 appears highly related to nucleotide diphosphate kinases (NDP). In humans, NDP kinases A and B are identical to two isotypes of human nm23 homologs, namely nm23-H1 and H2, respectively. nm23-H2 is identical in sequence to PuF, a transcription factor that binds to nuclease hypersensitive elements at positions 142 to 115 of the human c-Myc promotor. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

2°C to 8°C,RT

41116100