NNMT-IN-4 [2947393-64-6]

MedChem Express

NNMT-IN-4 [2947393-64-6]

5

2947393-64-6

Research Use Only

99.35

C9H11N3O

177.20

NNMT-IN-4 (compound 38) is a selective, uncompetitive and membrane permeability nicotinamide N-methyltransferase (NNMT) inhibitor with IC50 values of 42 and 38 nM in vitro biochemical and cell-based assays, respectively. NNMT-IN-4 shows favorable PK/PD and safety profiles as well as excellent oral bioavailability and pharmaceutical properties. NNMT-IN-4 can be used as a vivo chemical probe of NNMT[1].

C[C@@H]1CC2=C(N1)N=CC(C(N)=O)=C2

-20°C,2°C to 8°C

12131703