NNT1 antibody [11D28]

GeneTex

NNT1 antibody [11D28]

9

WB: 1:200 - 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Monoclonal

11D28

500 ug/ml

Unconjugated

CLCF1

cardiotrophin like cytokine factor 1

B-cell stimulatory factor 3; B-cell-stimulating factor 3; BSF3; BSF-3; cardiotrophin-like cytokine factor 1; CISS2; CLC; CRLF1 associated cytokine-like factor 1; neurotrophin-1/B-cell stimulating factor-3; NNT1; NNT-1; novel neurotrophin-1; NR6

Mouse

IgG2

Cardiotrophin-like cytokine factor 1

This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]

Human

-20°C or -80°C,2°C to 8°C

12352203