NO-Indomethacin [301838-28-8]

TargetMol Chemicals

NO-Indomethacin [301838-28-8]

44

301838-28-8

Research Use Only

NO-Indomethacin

C28H30ClN3O9S

620.07

NO-indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor. This drug design combines the anti-inflammatory properties of a non-steroidal anti-inflammatory drug (NSAID) with the gastrointestinal protective effects of NO. Compounds of this class retain their anti-inflammatory and analgesic activity, but have reduced gastrointestinal and kidney toxicity compared to the NSAID alone. NO-indomethacin also enhances the cancer chemopreventative activity of indomethacin. NO-indomethacin exhibits an IC50 of 82 microM, compared to >1,000 microM for indomethacin alone, for the inhibition of pancreatic cancer cell (PaCa-2) growth after 24 hours in culture.

3 years

COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)SC[C@@H](NC(C)=O)C(=O)OCCCCON(=O)=O)c2c1

-20°C

12352200