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NOD1/2 antagonist-1 [2704623-69-6]

HY-146034
MedChem Express
CAS Number2704623-69-6
Product group Chemicals
Molecular Weight663.03
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Overview

  • Supplier
    MedChem Express
  • Product Name
    NOD1/2 antagonist-1 [2704623-69-6]
  • Delivery Days Customer
    10
  • CAS Number
    2704623-69-6
  • Certification
    Research Use Only
  • Molecular Formula
    C32H28ClF5N4O4
  • Molecular Weight
    663.03
  • Scientific Description
    NOD1/2 antagonist-1 (compound 36b) is a potent NOD1/2 (nucleotide-binding oligomerization domain-like receptor 1/2) dual antagonist, with IC50 values of 1.13 (NOD1) and 0.77 microM (NOD2), respectively. NOD1/2 antagonist-1 has a acceptable T1/2 (67.6 min). NOD1/2 antagonist-1 (compound 36b) can improve the antitumor efficacy of Paclitaxel (PTX)[1].
  • SMILES
    O=C(C1=C(C=C2C(N(C=NC2=C1)CC(N3CCCC(F)(C3)F)=O)=O)C4=CC(Cl)=CC=C4)NCCCOC5=CC=C(C=C5)C(F)(F)F
  • UNSPSC
    12131703