nor-NOHA HCl

Biorbyt

nor-NOHA HCl [291758-32-2]

10

291758-32-2

Research Use Only

C5H12N4O3

176.1737804

nor-NOHA, also known as N-?Hydroxy-?nor-?L-?Arginine, is an Arginase inhibitor. nor-NOHA induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. Nor-NOHA can induce cell apoptosis and inhibit the ability of invasion and migration of HepG2 cells by inhibiting Arg1, which is related with the increase of iNOS expression and the high concentration of NO.

O=C(O)[C@@H](N)CCN/C(N)=N/O.[H]Cl.[H]Cl

12352200