Norquetiapine [5747-48-8]

MedChem Express

Norquetiapine [5747-48-8]

5

5747-48-8

Research Use Only

99.95

C17H17N3S

295.411

Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC50 of 13.9 microM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT1A (Ki = 45 nM) receptor agonist, and acts as an antagonist at presynapticalpha2 (Ki = 237 nM), 5-HT2C(Ki = 107 nM), and 5-HT7 (Ki = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation[1][2][3][4][5].

C12=CC=CC=C1N=C(C3=CC=CC=C3S2)N4CCNCC4

-20°C

12352200