Norquetiapine-d8 [1189866-35-0]

MedChem Express

Norquetiapine-d8 [1189866-35-0]

10

1189866-35-0

Research Use Only

C17H9D8N3S

303.45

Norquetiapine-d8 (N-Desalkylquetiapine-d8) is the deuterium labeled Norquetiapine.Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC50 of 13.9 microM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT1A (Ki = 45 nM) receptor agonist, and acts as an antagonist at presynapticalpha2 (Ki = 237 nM), 5-HT2C(Ki = 107 nM), and 5-HT7 (Ki = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation[1][2][3][4][5].

[2H]C1([2H])C([2H])([2H])NC([2H])([2H])C([2H])([2H])N1C2=NC3=CC=CC=C3SC4=CC=CC=C24

12352200