notch1a Antibody, Biotin conjugated

Cusabio

notch1a Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

notch1a

notch receptor 1a

de; deadly seven; des; n; n1a; neurogenic locus notch homolog protein 1; not; notch 1; notch 1a; notch homolog 1a; wu:fc01e02; wu:fc37a0; wu:fc37a05

Rabbit

IgG

Neurogenic locus notch homolog protein 1

Functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis (By similarity). Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity).

Zebra Fish

-20°C or -80°C

12352203