NPS-2143 (hydrochloride)

MedChem Express

NPS-2143 (hydrochloride) [324523-20-8]

10

324523-20-8

Research Use Only

99.80

C24H26Cl2N2O2

445.38

NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca 2+ concentrations ( IC 50 =43 nM) elicited by activating the Ca 2+ receptor in HEK 293 cells expressing the human Ca 2+ receptor [1] [2] .

N#CC1=C(OC[C@@H](CNC(C)(C)CC2=CC=C3C=CC=CC3=C2)O)C=CC=C1Cl.[H]Cl

2°C to 8°C

12352200