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IHC-P analysis of human breast adenocarcinoma tissue using GTX84007 NRBP1 antibody [5C3]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.
IHC-P analysis of human breast adenocarcinoma tissue using GTX84007 NRBP1 antibody [5C3]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.
IHC-P analysis of human breast adenocarcinoma tissue using GTX84007 NRBP1 antibody [5C3]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min.

NRBP1 antibody [5C3]

GTX84007
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Monkey
TargetNRBP1
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Overview

  • Supplier
    GeneTex
  • Product Name
    NRBP1 antibody [5C3] - Overexpression Validated
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:2000. ICC/IF: 1:100. IHC-P: 1:50. FACS: 1:100. IP: 2ug/500ul. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    5C3
  • Concentration
    1.48 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID29959
  • Target name
    NRBP1
  • Target description
    nuclear receptor binding protein 1
  • Target synonyms
    BCON3; MADM; MUDPNP; multiple domain putative nuclear protein; myeloid leukemia factor 1 adaptor molecule; NRBP; nuclear receptor-binding protein
  • Host
    Mouse
  • Isotype
    IgG2b
  • Protein IDQ9UHY1
  • Protein Name
    Nuclear receptor-binding protein
  • Scientific Description
    May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.
  • Reactivity
    Human, Monkey
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer.
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  • NRBP1 negatively regulates SALL4 to reduce the invasion and migration, promote apoptosis and increase the sensitivity to chemotherapy drugs of breast cancer cells. Yang C et al., 2022 Apr, Oncol Lett
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  • NRBP1 is downregulated in breast cancer and NRBP1 overexpression inhibits cancer cell proliferation through Wnt/beta-catenin signaling pathway. Wei H et al., 2015, Onco Targets Ther
    Read more