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NRIP antibody

Name: NRIP antibody
SKU: GTX105954_G10
Availability: BackOrder

GTX105954

ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetDCAF6

Overview

Supplier
GeneTex
Product Name
NRIP antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID55827
Target name
DCAF6
Target description
DDB1 and CUL4 associated factor 6
Target synonyms
1200006M05Rik, ARCAP, IQWD1, MSTP055, NRIP, PC326, DDB1- and CUL4-associated factor 6, IQ motif and WD repeat-containing protein 1, IQ motif and WD repeats 1, androgen receptor complex-associated protein, nuclear receptor interaction protein
Host
Rabbit
Isotype
IgG
Protein IDQ58WW2
Protein Name
DDB1- and CUL4-associated factor 6
Scientific Description
Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Tsai LK, Chen IH, Chao CC, et al. Autoantibody of NRIP, a novel AChR-interacting protein, plays a detrimental role in myasthenia gravis. J Cachexia Sarcopenia Muscle. 2021,12(3):665-676. doi: 10.1002/jcsm.12697
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Chen HH, Fan P, Chang SW, et al. NRIP/DCAF6 stabilizes the androgen receptor protein by displacing DDB2 from the CUL4A-DDB1 E3 ligase complex in prostate cancer. Oncotarget. 2017,8(13):21501-21515. doi: 10.18632/oncotarget.15308
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Chang SW, Tsao YP, Lin CY, et al. NRIP, a novel calmodulin binding protein, activates calcineurin to dephosphorylate human papillomavirus E2 protein. J Virol. 2011,85(13):6750-63. doi: 10.1128/JVI.02453-10
Read this paper