NS4591 [273930-52-2]
HY-120059
CAS Number273930-52-2
Product group Chemicals
Molecular Weight259.13
Overview
- SupplierMedChem Express
- Product NameNS4591 [273930-52-2]
- Delivery Days Customer9
- CAS Number273930-52-2
- CertificationResearch Use Only
- Molecular FormulaC11H12Cl2N2O
- Molecular Weight259.13
- Scientific DescriptionNS4591 is a modulator of calcium-activated potassium channels with activity that enhances small (SK) and intermediate (IK) conductivity. NS4591 doubled IK-mediated currents in whole-cell patch-clamp experiments at a concentration of 45 +/- 6 nM, and doubled SK3-mediated currents at a concentration of 530 +/- 100 nM. NS4591 inhibits the number of action potentials generated by suprathreshold depolarizing pulses in acutely isolated bladder primary afferent neurons. NS4591 also reduced carbakol-induced detrusor ring contraction in the rat bladder, demonstrating sensitivity to apamin[1].
- SMILESO=C1N(C2=C(C(Cl)=CC=C2N1CC)Cl)CC
- UNSPSC12352200