NSC 194308 [90379-42-3]

TargetMol Chemicals

NSC 194308 [90379-42-3]

16

Research Use Only

C12H22N2O3S2

306.44

NSC 194308, an enhancer of U2AF2-RNA complexes, promotes the association of the U2AF1-U2AF2-SF1-splice site RNA complex by targeting a site between U2AF2 RNA recognition motifs (RRM1 and RRM2). It inhibits pre-mRNA splicing by stalling spliceosome assembly at the stage where U2AF recruits U2 snRNP to the branchpoint. Additionally, NSC 194308 strengthens the binding of pre-mRNA to U2AF2, selectively inducing cell death in leukemia cell lines with spliceosome mutations [1].

C(NC(CSS(=O)(=O)O)=N)C1C2C(C)(C)C(C2)CC1

-20°C

12352200