NSC 663284

MedChem Express

NSC 663284 [383907-43-5]

10

383907-43-5

Research Use Only

99.56

C15H16ClN3O3

321.76

NSC 663284 (DA-3003-1) is a potent, cell-permeable, and irreversible Cdc25 dual specificity phosphatase inhibitor, has an IC 50 for Cdc25B2 of 0.21 microM. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B(2), and Cdc25C with Ki values of 29, 95, and 89 nM, respectively [1] . NSC 663284 inhibits NSD2 ( IC 50 of 170 nM) through a direct interaction with the catalytic SET domain ( K d of 370 nM) [2] .

O=C(C(Cl)=C1NCCN2CCOCC2)C3=C(N=CC=C3)C1=O

-20°C,2°C to 8°C

12352200