NSC 95397

MedChem Express

NSC 95397 [93718-83-3]

10

93718-83-3

Research Use Only

99.0

C14H14O4S2

310.39

NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor (Ki=32 nM (Cdc25A), 96 nM (Cdc25B), 40 nM (Cdc25C); IC50=22.3 nM (human Cdc25A), 56.9 nM (human Cdc25C), 125 nM (Cdc25B))[1]. NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway[2].

O=C1C(SCCO)=C(SCCO)C(C2=C1C=CC=C2)=O

-20°C

12352200