NSC139021 [1147-56-4]

MedChem Express

NSC139021 [1147-56-4]

10

1147-56-4

Research Use Only

99.86

C13H9N3OS

255.30

NSC139021 (ERGi-USU) is a RIOK2 inhibitor with anticancer activity. RIOK2 can highly selectively inhibit the growth of ERG-positive cancer cells with IC50s of 30-400 nM against cell lines. RIOK2 also causes cell cycle arrest and apoptosis in glioblastoma via induction of Skp2 and Skp2-p27/p21-Cyclin E/CDK2-pRb signaling[1][2].

OC1=C(/N=N/C2=NC=CS2)C3=CC=CC=C3C=C1

-20°C,2°C to 8°C

12352200