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Chemical Structure
Chemical Structure
Chemical Structure

NU6102 [444722-95-6]

Research Use Only
AG-CR1-0020
AdipoGen Life Sciences
CAS Number444722-95-6
Product group Chemicals
Estimated Purity>98%
Molecular Weight402.5
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Packing Size
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    NU6102 [444722-95-6]
  • Delivery Days Customer
    10
  • CAS Number
    444722-95-6
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Warning
  • Molecular Formula
    C18H22N6O3S
  • Molecular Weight
    402.5
  • Scientific Description
    Chemical. CAS: 444722-95-6. Formula: C18H22N6O3S. MW: 402.5. Potent CDK1/cyclin B (IC50 = 9.5 nM) and CDK2/cyclin A3 (IC50 = 5.4 nM) inhibitor. 1000-fold more potent than NU2058. Selective for CDK1 and CDK2 compared to CDK4/D1 (IC50 = 1.6 microM), DYRK1A (IC50 = 0.9 microM), PDK1 (IC50 = 0.8 microM) and ROCK-II (IC50 = 0.6 microM). Inhibits cell growth. - Potent CDK1/cyclin B (IC50 = 9.5 nM) and CDK2/cyclin A3 (IC50 = 5.4 nM) inhibitor [1-3]. 1000-fold more potent than NU2058 [1]. Selective for CDK1 and CDK2 compared to CDK4/D1 (IC50 = 1.6 microM), DYRK1A (IC50 = 0.9 microM), PDK1 (IC50 = 0.8 microM) and ROCK-II (IC50 = 0.6 microM) [1]. Inhibits cell growth [1].
  • SMILES
    NS(=O)(=O)C1=CC=C(NC2=NC3=C(N=CN3)C(OCC3CCCCC3)=N2)C=C1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor: T.G. Davies, et al.; Nat. Struct. Biol. 9, 745 (2002)
  • N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2: I.R. Hardcastle, et al.; J. Med. Chem.47, 3710 (2004)
  • Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2: K.L. Sayle, et al.; Bioorg. Med. Chem. Lett. 13, 3079 (2003)