NUPR1 Antibody

Cusabio

NUPR1 Antibody

20

ImmunoFluorescence, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

NUPR1

nuclear protein 1, transcriptional regulator

COM1, P8, nuclear protein 1, candidate of metastasis 1, nuclear protein, transcriptional regulator, 1, nuclear transcriptional regulator protein 1, protein p8

Rabbit

IgG

Nuclear protein 1

Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 Lys-16 acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.

Human

-20°C or -80°C

41116161