NVP 231 [362003-83-6]

MedChem Express

NVP 231 [362003-83-6]

10

362003-83-6

Research Use Only

99.73

C25H25N3O2S

431.55

NVP 231 is a potent, specific, and reversible ceramide kinase (CerK) inhibitor(IC50=12 nM) that competitively inhibits binding of ceramide to CerK[1]. NVP 231 induces cell apoptosis by increasing DNA fragmentation and caspase-3 and caspase-9 cleavage[2].

O=C(C1(C[C@@H](C2)C3)C[C@@H]3C[C@@H]2C1)NC4=CC=C5N=C(NC(C6=CC=CC=C6)=O)SC5=C4

-20°C,2°C to 8°C

12352200