NVP-AUY922 [747412-49-3]

BPS Bioscience

NVP-AUY922

7

747412-49-3

Research Use Only

≥99%

C26H31N3O5

465.5 Da

NVP-AUY922 potently inhibits HSP90 with IC50 values of 7.8 nM and 21 nM, and Ki values of 9 nM and 8.2 nM for HSP90alpha and HSP90beta, respectively. NVP-AUY922 shows a very high binding affinity to HSP90beta with a Kd of 1.7 nM. NVP-AUY922 inhibits the proliferation of human tumor cells in vitro with GI50 values of approximately 2 to 40 nM, inducing G1-G2 arrest and apoptosis. Human endothelial cells are very sensitive to NVP-AUY922 with GI50s of 2.5-3.9 nM. NVP-AUY922 also exhibits potent antitumor efficacy in human tumor xenografts including BT474 breast, A2780 ovarian, U87MG glioblastoma, PC3 prostate, and WM266.4 melanoma.

-20°C

51202000