NVP-CLR457 [1453082-52-4]

MedChem Express

NVP-CLR457 [1453082-52-4]

10

1453082-52-4

Research Use Only

C18H20F3N7O4

455.39

NVP-CLR457 (compound 40) is an orally active, potent and balanced pan-class I PI3K inhibitor. NVP-CLR457 shows a clear dose-dependent PK/PD/efficacy relationship. NVP-CLR457 has antitumor activity[1].

NC1=NC(C(F)(F)F)=C(C2=NC(N3CCOCC3)=NC(N4[C@H]([C@H](OC4=O)C)CO)=C2)C=N1

12131703