O-Desmethyl gefitinib

MedChem Express

O-Desmethyl gefitinib [847949-49-9]

10

847949-49-9

Research Use Only

99.40

C21H22ClFN4O3

432.88

O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC 50 of 36 nM in subcellular assays [1] [2] .

OC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN4CCOCC4

-20°C,2°C to 8°C

12352200